Association of Antigen-Specific T-cell Responses with Antigen Expression and Immunoparalysis in Multiple Myeloma
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چکیده
منابع مشابه
Association of antigen-specific T-cell responses with antigen expression and immunoparalysis in multiple myeloma.
PURPOSE Cancer testis antigens (CTA) are immunotherapeutical targets aberrantly expressed on multiple myeloma cells, especially at later stages, when a concomitant immunoparesis hampers vaccination approaches. EXPERIMENTAL DESIGN We assessed the expression of the multiple myeloma antigen HM1.24 (reported present in all malignant plasma cells) and the CTAs MAGE-A2/A3 and NY-ESO-1 (aberrantly e...
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Running title: Antigen-expression and specific T-cell responses in Myeloma th framework program OVER-MyR. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Despite a variety of therapeutical approaches including high dose chemotherapy with subsequent autologous stem cell transplantation, Multiple Myeloma remains an almost incurable disease. Ne...
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Purpose: Cancer testis antigens (CTA) are immunotherapeutical targets aberrantly expressed on multiple myeloma cells, especially at later stages, when a concomitant immunoparesis hampers vaccination approaches. Experimental Design: We assessed the expression of the multiple myeloma antigen HM1.24 (reported present in all malignant plasma cells) and the CTAs MAGE-A2/A3 and NYESO-1 (aberrantly ex...
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Background & Objective Angiogenesis is an essential component of tumor growth. Expression of PSMA on the neo-vasculature of many solid tumors, including glioblastoma multi-form, has been determined. The pattern of expression suggests that PSMA may play a functional role in angiogenesis. Methods: expression of PSMA in dif...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2015
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-14-1618